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Displaced Saints rout Packers, 38-3

JACKSONVILLE, Fla. (AP) — Jameis Winston and the hurricane-displaced Saints looked right at home in northeast Florida against Green Bay with a 38-3 victory — no doubt to the delight of fans rebuilding homes and lives back in New Orleans.

Winston passed for five touchdowns, New Orleans intercepted reigning NFL MVP Aaron Rodgers twice, and the Saints kicked off the post-Drew Brees era with a strikingly dominant opening victory over the Green Bay Packers on Sunday.

The game, originally scheduled for the Superdome, was moved while the New Orleans area continues to clean up wreckage left by Hurricane Ida, which struck southeast Louisiana as a Category 4 storm on Aug. 29, 16 years to the day after Hurricane Katrina devastated the same region.

Chiefs 33, Browns 29

KANSAS CITY, Mo. (AP) — Patrick Mahomes threw for 337 yards and three touchdowns while running for another score, and the Chiefs came back from a dismal first half in a rematch of their divisional playoff game from January.

Tyreek Hill caught 11 passes for 197 yards and a touchdown, and Travis Kelce hauled in a pair of TD catches, including the go-ahead score as the Chiefs finished off their rally from a 22-10 halftime deficit.

Dolphins 17, Patriots 16

FOXBOROUGH, Mass. (AP) — Tua Tagovailoa threw a go-ahead touchdown pass to Jaylen Waddle in the third quarter and Xavien Howard recovered a fumble with New England driving in the fourth.

It was Miami’s second straight win over the Patriots. Tagovailoa also led the Dolphins to a victory in the second meeting between the teams last season.

Cardinals 38, Titans 13

NASHVILLE, Tenn. (AP) — Kyler Murray scored five touchdowns and linebacker Chandler Jones had a career-high five sacks.

Jones, who tied the franchise record, had three sacks in a first quarter so good LeBron James chimed in on social media for his Defensive Player of the Year candidacy. Jones, who wants a new contract, also forced two fumbles the Cardinals turned into 14 points.

Seahawks 28, Colts 16

INDIANAPOLIS (AP) — Russell Wilson threw three of his four touchdowns in the first half as the defending NFC West champions won the 12th of their past 13 games in the early Sunday timeslot.

Indy lost its eighth straight opener, the past five with different starting quarterbacks.

49ers 41, Lions 33

DETROIT (AP) — Dre Greenlaw returned an interception for a touchdown to help the 49ers score 17 points over two-plus minutes late in the first half.

San Francisco led 38-10 early in the fourth quarter and allowed Detroit to score 23 points in three-plus minutes to pull within eight points. But the Lions turned the ball over on downs at the San Francisco 24 with 12 seconds left after getting it back on a fumble by Deebo Samuel.

Texans 37, Jaguars 21

HOUSTON (AP) — Tyrod Taylor threw for 291 yards and two touchdowns filling in for Deshaun Watson in a win over Trevor Lawrence and the mistake-prone Jaguars.

Taylor took over at quarterback for Houston with Watson’s future with the team uncertain after 22 women filed lawsuits alleging sexual assault or harassment after he requested a trade.

Chargers 20, Washington 16

LANDOVER, Md. (AP) — Justin Herbert threw for 337 yards and a touchdown in an ugly Week 1 matchup full of turnovers and big penalties.

Herbert led scoring drives of 75, 76 and 68 yards, and a go-ahead touchdown pass to Mike Williams made up for his fumble into the end zone and red zone interception on consecutive possessions. The reigning AP Offensive Rookie of the Year and the Chargers went 14 of 19 on third downs, wearing down Washington’s defense led by last year’s top defensive rookie, Chase Young.

Eagles 32, Falcons 6

ATLANTA (AP) — Jalen Hurts threw three touchdown passes, the first of them to Heisman Trophy winner DeVonta Smith, and the Eagles made a winner of Nick Sirianni in his head coaching debut.

Now firmly entrenched as the Eagles starter after Carson Wentz was traded, Hurts certainly looked the part with touchdown passes of 18 yards to Smith, 9 yards to Dallas Goedert and 23 yards to Jalen Reagor. Another Philadelphia rookie, fifth-round pick Kenneth Gainwell, scored his first TD as a pro with an 8-yard run late in the third quarter.

Bengals 27, Vikings 24, OT

CINCINNATI (AP) — Evan McPherson kicked a 33-yard field goal as time expired in overtime. The winning kick was set up by a gutsy call. On fourth-and-inches from the Cincinnati 48, Joe Burrow rolled out and hit tight end C.J. Uzomah in stride for a 32-yard gain and get McPherson well within his range. McPherson had a 53-yard field goal early in the fourth quarter.

Panthers 19, Jets 14

CHARLOTTE, N.C. (AP) — Sam Darnold threw for 279 yards and a touchdown and ran for another score against his former team. Darnold connected on a 57-yard touchdown pass with fellow ex-Jet Robby Anderson and took full advantage of a healthy Christian McCaffrey, who piled up 187 yards from scrimmage on 30 touches after missing 13 games last season with injuries.

Broncos 27, Giants 13

EAST RUTHERFORD, N.J. (AP) — Teddy Bridgewater threw two touchdowns in his first start for Denver and the Broncos dominated possession.

Acquired in the offseason from Carolina, Bridgewater completed 28 of 36 passes for 264 yards, sharing the ball with nine receivers. The 28-year-old QB hit Tim Patrick on a go-ahead 2-yard TD pass with :08 left in the half.

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